Nutrigenetics can help prevent the development of many diseases such as osteoporosis, which involves - among others - the vitamin D receptor polymorphism. The latter intervenes in the metabolism of calcium by the body making it essential to the construction of the bones and gives it a major role in the prevention of osteoporosis.
Vitamin D receptor polymorphism
The gene allowing to "make" the vitamin D receptor exists in several forms. Indeed, researchers have identified two different alleles called b or B. Some studies have highlighted that individuals with allele B have more risk of osteoporosis. In 2000, Danish researchers compared two groups of people with or without osteoporosis. They then noticed that B/B and B/b genotypes were most commonly associated with the risk of osteoporosis. Conversely b/b genotype would seem to 'protect' of this disease. "But this genotype does not allow him alone to predict the risk of osteoporosis, said Dr. Baranova, should look at associations between genes and watch their expression.
In the case of osteoporosis researchers analyzing therefore firstly vitamin D receptor polymorphism but they also look the genes involved in the synthesis of the estrogen receptor and collagen. "Analysis of these three groups of genes to have a more precise idea of the susceptibility of the patient to osteoporosis," says the researcher. So far only genetic analysis is not enough, it must also look at the way of life and the environment of the patient. "If we consider two women with the same profile for these groups of genes but only one practice regular physical activity and eat in a balanced way while the other does not sport and eat poorly, their risk of osteoporosis will be not the same", she explains.
Can we rely on the genetic profile to try to prevent the loss of bone density? "Yes you can use it, replied the expert. If it identifies a patient at risk on the basis of his DNA profile, can supplement it with vitamin D, calcium but also manganese, boron and magnesium to prevent bone loss and reduce the risk of osteoporosis. »
DNA metabolism
DNA (deoxyribonucleic acid) is the support of genetic information. It is a very long molecule compacted in the form of chromosomes and consist of genes. These genes can exist in different forms called alleles, polymorphisms.
The genetic information carried by DNA is translated into RNA and then expressed as proteins such as for example the enzymes necessary for metabolism. According to the alleles that we possess, we produce therefore not all of the same proteins in the same quantities, which explains that metabolism differs from one individual to another.
Vitamin D receptor polymorphism
The gene allowing to "make" the vitamin D receptor exists in several forms. Indeed, researchers have identified two different alleles called b or B. Some studies have highlighted that individuals with allele B have more risk of osteoporosis. In 2000, Danish researchers compared two groups of people with or without osteoporosis. They then noticed that B/B and B/b genotypes were most commonly associated with the risk of osteoporosis. Conversely b/b genotype would seem to 'protect' of this disease. "But this genotype does not allow him alone to predict the risk of osteoporosis, said Dr. Baranova, should look at associations between genes and watch their expression.
In the case of osteoporosis researchers analyzing therefore firstly vitamin D receptor polymorphism but they also look the genes involved in the synthesis of the estrogen receptor and collagen. "Analysis of these three groups of genes to have a more precise idea of the susceptibility of the patient to osteoporosis," says the researcher. So far only genetic analysis is not enough, it must also look at the way of life and the environment of the patient. "If we consider two women with the same profile for these groups of genes but only one practice regular physical activity and eat in a balanced way while the other does not sport and eat poorly, their risk of osteoporosis will be not the same", she explains.
Can we rely on the genetic profile to try to prevent the loss of bone density? "Yes you can use it, replied the expert. If it identifies a patient at risk on the basis of his DNA profile, can supplement it with vitamin D, calcium but also manganese, boron and magnesium to prevent bone loss and reduce the risk of osteoporosis. »
DNA metabolism
DNA (deoxyribonucleic acid) is the support of genetic information. It is a very long molecule compacted in the form of chromosomes and consist of genes. These genes can exist in different forms called alleles, polymorphisms.
The genetic information carried by DNA is translated into RNA and then expressed as proteins such as for example the enzymes necessary for metabolism. According to the alleles that we possess, we produce therefore not all of the same proteins in the same quantities, which explains that metabolism differs from one individual to another.
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